First & Goal: Thursday, Sept. 22, 2022
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Thursday, September 22
| Visiting Team | Score | Home Team | Score | Time |
|---|---|---|---|---|
| Vela | 21 | PSJA North | 28 | FINAL |
| Palmview | 21 | McAllen Memorial | 12 | FINAL |
| Laredo United | 49 | Harlingen at Roma | 56 | FINAL |
| Mercedes | 48 | Sharyland | 25 | FINAL |
| La Villa | 38 | MMA | 14 | FINAL |
| PSJA SW | 13 | Edinburg North | 35 | FINAL |
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